Our analysis identified several canonical pathways that were enriched in the DEmiRs target proteins and that were relevant to steatosis and NAFLD, including HIF1a, mTOR, TGF-b, PTEN, PPAR, NF-kB, insulin receptor, PI3K/AKT, hepatic fibrosis /hepatic stellate cell activation, and hepatic fibrosis signaling pathways (Figure 4A,B). Here, INSR is linked to metabolic dysfunction-associated steatotic liver disease.