ATP7A and Dravet syndrome: In particular, DS cases showed significantly higher pathological grading of neuropil threads (NTs) in immunohistochemistry for AT8 and AT180 (Figure 5A; p < 0.01 for both), and WM pathological grading in immunohistochemistry for AT8, AT180, Alz50, and MC1 (Figure 5A; p = 0.01, 0.01, < 0.01, 0.03, respectively).