During such a reversion, cancer cells re-express several previously repressed genes, including those involved in cell plasticity (Oct4, SOX-2, and Nanog), while genes (PSEN1, Notch-1) and proteins (SNAI1, αSMA, N-cadherin) supporting epithelial–mesenchymal transition (EMT) are downregulated [38]. This evidence concerns the gene NOTCH1 and cancer.