It is noteworthy that, during the dramatic progression of AMD-like pathology signs in OXYS rats, all the DEGs involved in the p38 MAPK SP turned out to be downregulated, though, among them, there were both activators (Map3k6 and Mapkapk3) and inhibitors (Dusp1) of the p38 MAPK SP. The gene discussed is DUSP1; the disease is age-related macular degeneration.