The manifestation of AMD-like pathology in 3-month-old OXYS rats occurred simultaneously with expression changes of six genes involved in the p38 MAPK SP: the mRNA expression of three genes (Mapk12, Ppm1d, and Taok3) increased and that of three genes (Irf1, Map3k5, and Txn1) declined (Figure 1e, Supplementary Table S2). This evidence concerns the gene TAOK3 and age-related macular degeneration.