CD142–FVIIa cleavage of protease activated receptors (PARs) causes transactivation of multiple receptor tyrosine kinases, including EGF receptor in keratinocytes, PDGF receptor β in monocytes, endothelial cell and fibroblasts, and IGF-1 receptor in breast cancer cells [35,36,37]. This evidence concerns the gene F3 and breast carcinoma.