F3 and cancer: When coagulation factor VII binds to CD142, it is converted to the active form factor VIIa, which in turn stimulates the activation of factors IX and X. Besides this function, and depending on the cellular context, CD142 may induce mitogen activated protein kinase (MAPK), phosphatidyl-inositol-3-kinase (PI3K), or Wnt signaling in cancers [15].