In conclusion, this study confirmed that APRIL/TNFSF13, BAFF, and MMP-3 are overexpressed in colorectal tumor tissues and the overexpression of APRIL/TNFSF13, BAFF, and MMP-3 indicates their potential relationship with unfavorable clinicopathological features and poor prognosis of CRC. The gene discussed is TNFSF13; the disease is colorectal carcinoma.