SERPINA1 had the potential to work as a diagnostic marker in BLCA (AUC = 0.711), CHOL (AUC = 0.952), ESAD (esophagus adenocarcinoma, AUC = 0.737), GBM (glioblastoma multiforme, AUC = 0.966), HNSC (AUC = 0.757), KICH (kidney chromophobe, AUC = 0.997), KIRC (AUC = 0.773), LIHC (AUC = 0.723), LUAD (AUC = 0.737), LUADLUSC (lung adenocarcinoma and lung squamous cell carcinoma, AUC = 0.854), LUSC (AUC = 0.984), OSCC (oral squamous cell carcinoma, AUC = 0.701), STAD (AUC = 0.703), THCA (AUC = 0.873), and UCEC (AUC = 0.715). Here, SERPINA1 is linked to glioblastoma.