INS and obesity due to melanocortin 4 receptor deficiency: PRSBMI was also found to be significantly associated with several obesity-related quantitative traits including systolic blood pressure (SBP) (p = 2.63 × 10−6), diastolic blood pressure (DBP) (p = 2.90 × 10−5), fasting insulin (INS0) (p = 8.15 × 10−3), high-density lipoprotein cholesterol (HDLC) (p = 9.07 × 10−3), and triglyceride (TG) (p = 2.50 × 10−2) (Table 2).