The most highly expressed transcript of each gene was compared between individuals diagnosed with ALS or ALSND and NNCs, identifying a significant difference in the expression of the HLA-A (ENST00000376809.10), ZNF780A (ENST00000450241.6), and TF (ENST00000402696.9) gene transcripts but not in the expression of AQP3 (ENST00000297991.6) in the spinal cord (Figure 6a–d). The gene discussed is AQP3; the disease is amyotrophic lateral sclerosis.