We have previously reported that colonic inflammation correlates with brain Aβ plaque deposition starting at 3 months of age in AppNL-G-F mice and increased pro-inflammatory markers and macrophages in the ileums of AppNL-G-F and APP/PS1 mice compared to controls and chronic intestinal disruption induced by two cycles of DSS exposure resulted in moderate colitis-like symptoms in WT and AppNL-G-F animals [35]. Here, APP is linked to colitis.