In another study, four biomarkers were evaluated (BNP, MMP-9, S100B and D-dimer), showing a sensitivity of 90% in predicting all types of strokes (sensitivity 90%, specificity 45%), intracranial haemorrhage (sensitivity 88%, specificity 38%), and ischemic stroke (sensitivity 91%, specificity 45%) within 3 h of symptom onset. This evidence concerns the gene NPPB and stroke disorder.