ESR2 and cancer: MiRNAs are also involved in the response to cancer treatment, in particular, miR-22 acts on estrogen receptor-β (Erβ) mRNA causing the inhibition of estrogens activity and, consequently, inducing an augment of cancer cells’ sensitivity to 5-fluorouracil, a drug commonly used in CRC; moreover, miR-22 regulates the so-called “B-cell translocation gene 1” that, in turn, modulates cell differentiation and growth [22].