This is true especially for primary glioblastoma, since in the recurrent forms it is downregulated and, consequently, stimulates Kirsten rat sarcoma virus (K-RAS), PBX homeobox 3 (PBX3), and matrix metallopeptidase 11 (MMP11) with the result of a promotion in cell migration and invasion. This evidence concerns the gene MMP11 and glioblastoma.