It is believed that neuronal accumulation of hyperphosphorylated tau (p-tau) contributes significantly to neuron dysfunction and death in Alzheimer’s disease (AD) and other tauopathies, including progressive supranuclear palsy (PSP), frontotemporal dementias, among others [18,19,20]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.