We have a similar concern about the majority (thousands) of authors who have published cancer cell “lethality” articles by merely relying on measuring cell “viability” (by high content multiwell plate assays), some ambiguous manifestations of apoptosis (e.g., caspase 3 activation), and/or proliferation arrest (“mitotic catastrophe”) as markers of cancer cell death. The gene discussed is CASP3; the disease is cancer.