APP and memory: In animal models, using an amyloid precursor protein (APP)/presenilin-1 (PS-1) double transgenic (TG) mouse model of AD, treatment with QUET attenuated memory impairment, decreased the number of β-amyloid (Aβ) plaques and up-regulated the cerebral anti-apoptosis B-cell lymphoma (Bcl)-2 protein [18].