CYP1B1 and cancer: In cancer cell studies, SP1 was considered a key mediator of CYP1B1 action, whilst CYP1B1 was shown to activate a epithelial to mesenchymal transition and Wnt/beta-catenin-signaling pathways, upregulating beta-catenin and other TFs, such as ZEB2 and SNAI1 [54].