Recently published Sleeping Beauty screens aiming at identifying genes involved in breast cancer initiation and progression characterized ANCO1 as a frequently lost gene in genetically engineered mouse models of Pik3caH1047R-, KrasG12D-, and Stat3c-induced breast cancer, emphasizing its suppressive role that hinders oncogene-driven aberrant transcription [9]. This evidence concerns the gene ANKRD11 and breast carcinoma.