The identified up-regulated genes with H3K27Ac engagement included the inflammatory response genes IL1α, IL1β, and SERPINB2; the HBEGF gene that mediates cell migration and invasion; PLAU, which is regulated by AP-1 and drives cancer metastasis; and LAMC2, which is involved in the EMT process [48,49,50]. The gene discussed is PLAU; the disease is cancer.