Recently published Sleeping Beauty screens aiming at identifying genes involved in breast cancer initiation and progression characterized ANCO1 as a frequently lost gene in genetically engineered mouse models of Pik3caH1047R-, KrasG12D-, and Stat3c-induced breast cancer, emphasizing its suppressive role that hinders oncogene-driven aberrant transcription [9]. The gene discussed is ANKRD11; the disease is breast cancer.