Aside from the most common constitutional symptoms, such as fever, pruritus and fatigue, anti-CTLA-4 is more associated with diarrhea (36%), colitis (8%) and hypophysitis (4%), while anti PD-1 and PD-L1 can lead more frequently to thyroiditis (8%) and pneumonitis (4%) [17,18]. The gene discussed is CTLA4; the disease is hypophysitis.