SLC22A2 and cancer: In this work, the role of mouse organic cation transporter 2 (mOCT2) in CDDP nephrotoxicity and peripheral neurotoxicity was investigated by comparing changes in renal and neurological functions in wild-type (WT) mice and mice with global genetic deletion of OCT2 under chronic cyclic CDDP treatment, a treatment protocol similar to cancer chemotherapeutic protocols used in patients.