HMOX1 and Parkinson disease: On the contrary, (a) a TSB decrease even below the level of the controls has accompanied the progression of this disease to the most severe stages; (b) genetic polymorphisms of HMOX1 have also been shown to decrease BV and bilirubin production, correlating with the early onset of PD, stressing once again the importance of YPs and the modulation of inflammation to prevent or delay the pathology [100,101,102,103,104,105].