BLVR induction and bilirubin increase have been reported to reduce hepatic steatosis [268,269], possibly through bilirubin binding to PPAR, as a central signaling pathway in obesity, which induces the fat-burning genes Cpt1, Ucp1, and Adrb3 (carnitine palmitoyltransferase 1A, uncoupling protein 1, adrenoceptor beta 3) [35,270]. This evidence concerns the gene UCP1 and obesity due to melanocortin 4 receptor deficiency.