CCL2 and hepatocellular carcinoma: The mechanism study revealed that upregulated A3B inhibited the enrichment of spherical H3K27me3 by interacting with multi-comb repressor complex 2, reducing H3K2me3 binding to the CCL2 promoter, activating CCL2 transcription in HCC cells, and recruiting a large number of MDSCs into the HCC microenvironment [90].