While our data and the literature do not explain the negative correlation observed between miR-124 and miR-132 in terms of circulation, several reports have shown that both miRNAs are potential tumor suppressors that regulate epithelial to mesenchymal transition (EMT) in cancer through the ZEB2/SMAD2/TGF-β pathway [78,101]. This evidence concerns the gene TGFB1 and neoplasm.