The PI3K/Akt signaling pathway that plays a central role in various physiological processes and mediates the biological effects of insulin and insulin-like growth factor-1 (IGF-1) is aberrantly activated in diabetes/IGT, obesity, and breast cancer suggesting a possible link between these comorbidities [27]. The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.