In ovarian cancer, reduction of PAX2 expression appears to be an early event of cancer clonal expansion, during which PAX2 has inhibitory effects on tumor invasion and metastasis, potentially through interactions involving multiple pathways, including between Phosphatase and tensin homolog (PTEN), PAX2, and Tumor protein p53 (TP53) [37,38]. Here, PTEN is linked to ovarian cancer.