Thus, in Ang II-dependent hypertension, ATP is released by the increased sheer stress and macula densa-mediated mechanisms, causing the stimulation of P2XR on renal afferent arterioles, then Ang II activates AT1R and may share intracellular signaling pathways, regulating the renal afferent arteriole tone. Here, AGTR1 is linked to hypertensive disorder.