In this study, we systematically described the expression patterns and clinical significance of FKBP10 in CRC and creatively found that the expression of FKBP10 in CRC tissue exhibits various distribution patterns: concentrated (FKBP10-C), transitional (FKBP10-T) and dispersive (FKBP10-D), which were related to the intracellular localization and function of FKBP10 in epithelium. Here, FKBP10 is linked to colorectal carcinoma.