Exon 6 encodes for the transmembrane domain of IL7R; therefore, its inclusion leads to a transmembrane-bound isoform, while skipping of exon 6 results in a soluble isoform of IL7R (sIL7R), which is involved in the pathogenesis of an autoimmune disease called multiple sclerosis (MS) [91]. This evidence concerns the gene IL7R and myeloid sarcoma.