The ApaI, BsmI, and TaqI polymorphisms were associated with higher severity of liver cirrhosis, as patients with BsmI and TaqI SNPs had a higher model for end-stage liver disease (MELD) score and were mainly in Child–Pugh (CP) stage C. ApaI SNP was also associated with increased levels of lipopolysaccharide-binding protein (LBP), IL-1β, IL-8, and CP stage C, whereas the CC genotype of the FokI SNP was associated with lower levels of IL-1β and was an independent prognostic factor for the survival of patients with cirrhosis. The gene discussed is IL1B; the disease is End Stage Liver Disease.