The presence of ApaI, BsmI, and TaqI SNPs in cirrhotic patients may have an impact on the progression of fibrosis and liver necrosis in cirrhosis, as it is associated with the expression of Gpx, plasma membrane Ca2+ ATPase (PMCA), and Jumonji domain containing 1A (JMJD1A) genes, which are involved in biological processes contributing to hepatocyte function, chronic liver injury, and fibrosis. The gene discussed is ATP2B2; the disease is digestive system neoplasm.