SYP and Alzheimer disease: Of interest, it was also noted that the overexpression of amyloid precursor protein (APP), typical for neurodegenerative disorders such as AD, decreased after administration of the PF-3845 inhibitor, and the expression of synaptophysin increased, which correlates with the potential positive effect on inhibiting or controlling the development of AD [30], further proving the neuroprotective effects of this compound.