ACHE and Alzheimer disease: Moreover, administration of JZL-195 led to a reduction in the level of beta amyloid in the mouse hippocampus via the blood–brain barrier, as well as a significant increase in the activity of acetylcholinesterase and butyrylcholinesterase enzymes was also observed, which seems to be helpful in the treatment of AD [18,40] and can point to another interesting non-ECS-related mechanism of its cognitive effects.