CDH1 and neoplasm: The actin cytoskeleton regulates the creation and stabilisation of β-catenin/E-cadherin complexes between adherent cells, which play a fundamental role in maintaining epithelial integrity and in controlling the activation of the wingless (Wnt)/β-catenin pathway, in which cytoplasmic β-catenin translocates into the nucleus and functions as an activator for transcription factors involved in cellular adhesion, tissue morphogenesis, and tumour development [18].