For instance, high amounts of thymic stromal lymphopoietin (TSLP) in patients with atopic dermatitis activate T helper (Th) cells to produce Th2 cytokines (e.g., Interleukine (IL)-4, IL-5), which in turn can directly lead keratinocytes to further produce more TSLP [32,33]. The gene discussed is IL4; the disease is atopic eczema.