NOTCH1 and neoplasm: Furthermore, to further assess the oncogenic effect of NOTCH1 on tumorigenicity in vivo, Su B et al. inoculated subcutaneous SACC cells, knock-down for NOTCH1, silenced by NOTCH1-specific siRNAs, into the flanks of athymic mice, demonstrating that by silencing the NOTCH1 gene, tumor growth may be inhibited by inducing cellular apoptosis [61].