Several non-coding RNAs, including LncRNA H19, LINC00968, LINC00628, LncRNA NDRG1, LncDANCR, and circ_001422, are markedly associated with the OS advanced clinical stage, larger tumor size, higher incidence of metastases, and poorer prognosis, and they have been found to be mediated through the PI3K/AKT signaling pathway [43,51,52,53,54,55]. The gene discussed is PIK3CA; the disease is neoplasm.