Extensive studies showed that the carriers of monoallelic PALB2 pathogenic variants (PVs) are predisposed to develop multiple types of cancer, including breast, pancreatic, and ovarian cancers [3,4,5]; the carriers of biallelic PALB2 PVs can cause the subtype N of Fanconi anemia (FA-N) [6]. The gene discussed is PALB2; the disease is Fanconi anemia.