These results reflect the findings of Dolatshad et al., who reported growth inhibition and induction of cell cycle arrest as a result of SF3B1 suppression in myeloid cells [54], and also provide evidence that the myeloid and lymphoid lineages of blood cells behave in a different way in response to SF3B1 knockdown, as myeloid lineage cancer cells showed a particular vulnerability to the consequences of SF3B1 suppression. Here, SF3B1 is linked to cancer.