SULT1A1 and acute kidney injury: We previously reported that the concentration of IS in the serum and kidney was lower in Sult1a1-deficient (Sult1a1-KO) cisplatin mice [16], and the increase of IS level could be due to the downregulation of renal organic ion transporters and central nervous system toxicities in cisplatin-induced AKI model rats [17,18].