Although FH displays broad genetic heterogeneity in general—the most frequent variant in Spain represents only 7% of FH cases [12]—almost 70% of FH cases with a positive genetic diagnosis in the island of Gran Canaria are due to a single mutation (p.[Tyr400_Phe402del]) in LDLR, which is associated with severe hypercholesterolaemia and increased cardiovascular risk [13]. This evidence concerns the gene LDLR and Hypercholesterolemia.