In previous studies, SOX18 silencing induced G0/G1 arrest in colorectal cancer, laryngeal, hepatocellular carcinoma, renal and blader cancer, while S-to-G2/M inhibition was observed in SOX18 knockdown osteosarcoma cells [14,16,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. The gene discussed is SOX18; the disease is osteosarcoma.