Vascular endothelial cells can also establish vascular niches by deploying various angiocrine factors such as TGFβ, hepatocyte growth factor (HGF), and Wnt signaling molecules to guide a variety of physiological processes, including liver regeneration, fibrosis, and NASH progression [41,57,79]. This evidence concerns the gene HGF and metabolic dysfunction-associated steatohepatitis.