Moreover, although senescence signaling usually upregulates IL-6 and IL-8 activity in an autocrine manner part of the pro-inflammatory factors termed the senescence-associated secretory phenotype (SASP) [49,50,51], in melanoma cells, these interleukins are commonly associated with high tumor growth and invasiveness linked to poor prognosis [51,52]. The gene discussed is CXCL8; the disease is neoplasm.