Similarly, Martins-Oliveira et al. [23] and Theodoro-Júnior et al. [24] used BbKI and EcTI as treatment in their experimental model of elastase-induced emphysema, and showed an attenuated response to oxidative stress, with a reduction in eNO and decreased expression of iNOS-positive cells in the alveolar septa and airways. Here, NOS2 is linked to pulmonary emphysema.