ABCC5 and cancer: First, we tested the ability of 1 to be taken up by human cancer cell lines of different histological origin (non-small cell lung cancer, NSCLC; triple negative breast cancer, TNBC; and pancreatic adenocarcinoma, PDAC), known for their intrinsic resistance to chemotherapy caused by the high levels of different ABC transporters, namely ABCB1, ABCC1, and ABCC5 present on the cell surface of each cell line, measured via flow cytometry (Table 1).