Notably, our CORM reduced the catalytic efficiency of the ABC transporters mostly expressed in each resistant cell lines, namely ABCC1, which transports cisplatin in NSCLC cells; ABCB1, the effluxer of doxorubicin and docetaxel in TNBC and ABCC5, the gemcitabine transporter in PDAC cells (Figure 4E). This evidence concerns the gene ABCC1 and non-small cell lung carcinoma.