SMAD4 and breast cancer: In breast cancer, Fascin-1 is responsible for invadopodia formation, migration and invasion of cancer cells, and it has been shown to be a direct target of the canonical Transforming Growth Factor β (TGFβ)-Smad4 signaling pathway which, in breast, has been found to be under the control of GATA-3 transcription factor, a factor involved in breast morphogenesis [26].