TARDBP and proteostasis deficiencies: Finally, exosomes released by primary neurons obtained from the cortex of postnatal day 1 Bl/C57 mice containing TDP-43 aggregates transfer pathological protein to neuro2a cells, causing a cytoplasmic redistribution of TDP-43 and suggesting a possible contribution of secreted exosomes to the propagation of TDP-43 proteinopathy.