Also in neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Creutzfeldt–Jakob disease (CJD), characterized by the aggregation, deposition, and spread of specific misfolded proteins Aβ and hyperphosphorylated Tau, α-synuclein, and the pathogenic form of the prion protein (PrPSc), respectively, a shedding of EVs by neuronal and non-neuronal cells has been reported [111]. Here, PRNP is linked to Alzheimer disease.