OPTN and amyotrophic lateral sclerosis: Superoxide dismutase 1 (SOD1), fused in sarcoma (FUS), chromosome 9 open reading frame 72 (C9orf72), optineurin (OPTN), TANK-binding kinase 1 (TBK1), and TAR DNA-binding protein 43 (TDP-43) are the most common mutated genetic forms in familial ALS cases, and different gene mutations can result in the same clinical phenotype, while diverse clinical phenotypes can result from the same mutant gene [8].