Furthermore, HCT116-derived tumorspheres with overexpression of typical colon CSC markers (CD133, CD44, CD24, SOX2 NANOG, and Oct-4) [39,40,41] showed a reduction in their viability after treatment with 40% W and W/O fractions of A. sulcata as is the case with numerous marine-derived compounds, such as fucoxanthinol or sphaerococcenol A [42,43,44,45], which are of great importance in the prevention of tumor self-regeneration and cell resistance to conventional drugs. Here, POU5F1 is linked to neoplasm.