Tay et al. followed 14 subjects with MCI and 74 with mild to moderate AD and measured the scores for the Clinical-Dementia-sum of boxes (CDR-SB) at baseline and after one year and assessed the correlations between changes in the CDR-SB and serum levels of Dickkopf-1 (Dkk-1), which is an antagonist of Wnt [29]. The gene discussed is DKK1; the disease is Alzheimer disease.