TGFB1 and Alzheimer disease: The purpose of this article is to suggest a cure for AD based upon the tentative explanation of the above paradox, which, expectedly, is multifactorial and complex: the barrier to curing AD is the combined effects of decreased levels of transforming growth factor beta (TGF-β) and of Wnt/β-catenin signaling, an alteration of epithelial-mesenchymal transition (EMT), plus important risk factors particular to each patient in the year preceding the transition from MCI to AD.