Aflibercept is a fully human, recombinant synthesis protein that binds as a ligand to vascular-endothelial-growth-factor (VEGF) family members, including VEGF-A and VEGF-B, and is indicated for the treatment of retinal edema due to several disease entities, such as retinal vein occlusion [26,27] and diabetic macular edema [28]. This evidence concerns the gene VEGFA and retinal edema.