There was a positive family history of maternal thrombophilia (MTHFR A1298C, MTHFR C677T, PAI-1 4G/5G promoter, and Factor XIII (Val34Leu) heterozygous gene mutations and Protein S deficiency), treated with enoxaparin and acetylsalicylic acid during pregnancy. This evidence concerns the gene SERPINE1 and Rare hereditary thrombophilia.