Furthermore, Co-19 seems to trigger the overexpression of the tripartite motif-containing protein 21 (E3 protein ligase TRIM21), which belongs to a tripartite motif protein family that is encoded by gene 21 and is an important autoantigen in autoimmune pathologies (Sjogren syndrome, systemic lupus erythematosus (SLE)). This evidence concerns the gene TRIM21 and systemic lupus erythematosus.