Furthermore, Co-19 seems to trigger the overexpression of the tripartite motif-containing protein 21 (E3 protein ligase TRIM21), which belongs to a tripartite motif protein family that is encoded by gene 21 and is an important autoantigen in autoimmune pathologies (Sjogren syndrome, systemic lupus erythematosus (SLE)). The gene discussed is TRIM21; the disease is Sjogren syndrome.