CX3CR1 and myocardial infarction: We have published several studies to demonstrate a clear link between CX3CR1 and MVO, which, together with unpublished experimental studies in a rat MI model (unpublished data [68]), led us to initiate and perform the first pilot study (FRACTAL, ISRCTN 18402242) in humans using a small molecule allosteric inhibitor of CX3CR1 (KAND567) in 70 patients with acute anterior MI (please see below under Section 6).