Importantly, in a previous study performed on 100 healthy postmenopausal women, a higher insulin resistance as well as higher triglyceride, VLDL and IL-6 levels were observed in the participants with higher estrogen levels (i.e., those in the third tertile of the serum estrogen concentrations), but these differences were explained by a concomitant increase in total adiposity [40]. This evidence concerns the gene IL6 and Insulin resistance.